AVVIO Enhanced Lithotripsy System

Our innovative ureteral stone treatment system combines several cutting-edge technologies to offer a more efficient alternative to traditional methods. At the heart of the system is microbubble-enhanced acoustic cavitation, which uses acoustic energy to break down ureteral stones with minimal force, unlike the more traumatic shock waves used in conventional treatments.

The system features a patented microbubbles with stone calcium seeking bisphosphonate ligands enhancing the communition process. A smart ureteral catheter, responsive to acoustic signals, enables precise real-time navigation within the ureter, eliminating the need for intraoperative imaging or stents.

This system advances ureteral stone treatment by offering a faster and more accessible solution, improving outcomes and expanding access to care.

At the core of our system is the use of microbubble-enhanced acoustic cavitation, which leverages acoustic energy to fragment ureteral stones with precision. This method uses lipid microbubbles that are designed to collect on the surface of the stone – a technology that enhances the cavitation process for more efficient and controlled stone comminution. Unlike traditional shock wave therapy, which uses high-pressure waves, our system delivers diagnostic ultrasound, potentially reducing trauma to surrounding tissues.

Calcium-seeking microbubbles are activated by the system’s low-pressure ultrasound, creating millions of micro-jets that help break down stones.

The ELS Console is the heart of the system, providing clinicians with real-time oversight and intuitive control of all components. It seamlessly integrates with the microbubble actuation and the smart ureteral catheter, allowing the operator to monitor the procedure and make adjustments as necessary. The console features an easy-to-use interface that displays real-time feedback on catheter positioning and stone treatment progress.

The console enables precise management of the procedure, enhancing clinician confidence and efficiency. It also streamlines the workflow by consolidating all controls into one device, reducing the need for multiple machines or complex setups.

The treatment head is a unique phased-array transducer designed to emit and steer a beam of low-intensity focused ultrasound spanning approximately 6 cm of ureteral length. Steering the focused beam over 6 cm reduces the need for precise focusing on the target stone.

The reduced acoustic pressure minimizes the need for general anesthesia, offering a less painful, less invasive treatment with a faster recovery time.

The smart ureteral catheter is equipped with acoustic sensors that detect the energy waves in real-time. The signals are received and interpreted by the control console and allowing the user to precisely locate the catheter and position the treatment head on the patient’s skin without the need for intraoperative stents. This advanced technology ensures that the treatment head is always in the correct position enhancing the accuracy of the treatment. 

The smart catheter eliminates the need for stenting during the procedure, making it possible to perform the treatment in more accessible settings and simplifying the workflow for clinicians.