About Avvio - Founders

With 39 years of experience in the Hospitality and Medical Devices industries, Sanjay Rane is a seasoned professional specializing in strategic management, process optimization, and team leadership. Throughout his career, he has successfully overseen complex operations, implemented best practices, and driven efficiency to support organizational growth. His commitment to excellence, innovation, and continuous improvement has been instrumental in achieving operational success while fostering high-performing teams.

Abhishek has over 15 years of extensive experience in accounting, financial management, and general administration, having worked for multinational medical device companies such as Insightra Medical and CMR Surgical. With a keen eye for detail, he excels in financial analysis, modeling, budgeting, and forecasting, contributing to organizational growth and strategic decision-making.

His proven leadership track record, combined with expertise in streamlining financial processes, optimizing costs, and ensuring compliance, has played a key role in enhancing operational performance. Abhishek holds a Bachelor of Commerce (B. Com) specialized in Accountancy and MBA specialized in Corporate Finance.

Shruti Bhat has over 22 years of work experience in the multinational and start-up pharmaceutical and medical device organizations and academics, specializing in regulatory affairs, quality assurance, and manufacturing. She has a proven track record in ensuring compliance with global regulatory standards, leading quality management systems, and overseeing manufacturing processes. Shruti holds a Master’s degree in Pharmaceutical Sciences and Technology with Specialization in Quality Assurance.

Dr. Manisha Jadhav is an accomplished healthcare professional with over 15 years of diverse experience in clinical research, professional education & training, medical affairs, and hospital administration. She has held key leadership positions, including Global Vice President of Clinical & Operations at Integrated Endoscopy, USA, India Clinical Manager at Foldax Inc, Regional Operations & Clinical Lead at CMR Surgical. These roles reflect her vast expertise in managing complex operations and contributing to healthcare advancements.

Dr. Jadhav has extensive experience in clinical research operations & medical affairs across regions, including India, the Middle East, and Africa. As Operations Manager in previous organizations, she successfully built service and support teams, developed training pathways, clinical support and managed distributor networks. Her expertise spans regulatory compliance, clinical implementation, and commercialization support consulting, where she has led market entry strategies, coordinated surgical workshops, and improved regional operations to enhance customer satisfaction. An adept strategist in clinical trials, Dr. Jadhav has managed multiple global studies in diverse therapeutic areas, including cardiothoracic, general surgery, gynecology, and oncology. She has actively contributed to the development of medical devices and pharmaceuticals, overseeing study design, regulatory submissions, and safety reporting.

Dr. Jadhav’s contributions extend to hospital administration, where she implemented NABH protocols, managed clinical pathways, and directed hospital operations to improve healthcare delivery. As a thought leader, she has authored scientific manuscripts, participated in conferences, and collaborated with global key opinion leaders to advance medical research and education.

Laxmikant Khanolkar brings over 40 years of extensive experience in the pharmaceuticals and medical devices industry, having held key leadership positions at renowned global companies such as Edwards Lifesciences, Baxter Healthcare, and Glaxo. Throughout his career, he has been instrumental in driving business growth, spearheading strategic initiatives, and expanding market presence across diverse healthcare sectors. As the Chief Operating Officer of Insightra Pvt Ltd, Laxmi played a pivotal role in overseeing the development, commercialization, and distribution of cardiovascular products, ensuring innovation and market penetration. Most recently, Laxmi served as the Asia Pacific Head at CMR Surgical, where he led market expansion, sales strategy, and business development across the region, playing a crucial role in introducing and scaling robotic-assisted surgical technology in key markets. His leadership in navigating regulatory challenges, building strategic partnerships, and driving adoption of cutting-edge medical technologies has significantly contributed to the company's growth in the Asia Pacific region. With a deep understanding of the medical industry, regulatory landscape, and business operations, Laxmi continues to be a visionary leader, driving growth and innovation in the pharmaceutical and medical devices space.

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Dr. Marshall Stoller heads UCSF’s urinary stone division, which includes endourology and laparoscopy. Stoller graduated from the University of California at Berkeley in 1976 and went to medical school at Baylor College of Medicine in Houston, Texas. Following medical school, he returned to the SF Bay Area, where he was a general surgical intern and resident at UCSF from 1981-1983 and a urology resident from 1983-1985. Stoller presently operates at Moffitt-Long Hospital, San Francisco General Hospital and the San Francisco Veterans Affairs Medical Center. His practice emphasizes surgical management of urinary stone disease and minimally invasive endourology.

Remembering Robert Grubbs, Co-Founder of Applaud Medical

We are deeply sad to announce the passing of one of Avvio Medical’s Founders, Dr. Robert Grubbs. Dr. Grubbs was a prominent chemist who helped identify a “green chemistry” breakthrough for manufacturing of compounds that are used to make everything from plastics to pharmaceuticals with less hazardous waste. Dr. Grubbs won the Nobel Prize in Chemistry in 2005 along with Richard R. Schrock of the Massachusetts Institute of Technology and Yves Chauvin of the French Petroleum Institute. The three chemists shared the award equally for their work developing olefin metathesis, a key reaction for redistributing carbon-carbon bonds by breaking and then remaking carbon-carbon double bonds. This work paved the way for metathesis to become a cornerstone of chemical manufacturing. The catalysts they developed, which are named for them, are in wide use today in making chemicals for a variety of manufacturing processes.

Dr. Grubbs earned his B.S. and M.S. degrees at the University of Florida, then his Ph.D. from Columbia University. He spent a year at Stanford University as a NIH fellow before joining the faculty of Michigan State University in 1968. A decade later, he was hired by Caltech, where he became the Victor and Elizabeth Atkins Professor of Chemistry in 1990. Over his career, Grubbs advised and mentored more than 100 doctoral candidates and almost 200 postdoctoral associates while also co-founding several companies, Including Avvio Medical. Besides the Nobel Prize, Dr. Grubbs was the recipient of the Benjamin Franklin Medal from the Franklin Institute, the Arthur C. Cope Award from the American Chemical Society and the Gold Medal from the American Institute of Chemists. He was a member of the National Academy of Sciences, a fellow of the American Academy of Arts and Sciences and a member of the Honorable Order of Kentucky Colonels. He received honorary degrees from, among others, the Georgia Institute of Technology, the University of Crete in Greece, the University of Warwick in the United Kingdom, and Rheinisch-Westfälische Technische Hochschule Aachen University in Germany. He authored more than 400 papers and held 80 patents.

Avvio Medical recognizes Dr. Grubb’s legacy and will forever be grateful for his efforts as a co-founder of the company.

Dr. Thomas Kenny is Chief Science and Technology Advisor and Board Chairman of Avvio Medical. He also holds positions as Professor and Senior Associate Dean of Engineering at Stanford University. He was the Founder and CTO of Cooligy (now a division of Emerson), a microfluidics chip cooling component manufacturer, and Founder and a Board Member of SiTime Corporation (now on the Nasdaq : SITM), a market leader in timing references for consumer electronics using MEMS resonators.

Claire Mills is Ultrasound and Clinical Affairs Specialist of Applaud Medical supporting various clinical roles. She continues to work as a UCSF vascular research sonographer doing basic science studies along with clinical trials in areas of vascular effects of end stage renal disease, HIV, environmental impacts, vaccines, and other areas. Earlier, Mills worked at GlaxoSmithKline in pharmaceuticals then biologics and has worked as a medical text editor and in healthcare fundraising and lobbying. As a chronic kidney stone cystinuric patient, Mills was a driver in making Applaud a reality and is deeply committed to seeing this product come to market to improve the lives of other kidney stone patients.

Dr. Dan Laser was the Founding CEO of Applaud Medical. Laser is currently the CEO of Myka Labs, a company pioneering interventions for wide-ranging conditions involving the gastrointestinal tract, including pediatric congenital malformations, inflammatory bowel disease, and diseases of metabolism. Dan was CEO at Wave 80 from 2005 to 2015. Wave 80’s work in the HIV field meaningfully contributed to the pivot to pre-exposure prophylaxis and other novel approaches to curbing the HIV epidemic in the face of persistent challenges around HIV vaccine development. Dan continues to serve on Wave 80’s Board of Directors. As founding CEO of Applaud, Dan oversaw the company’s successful development of a new class of therapeutic interventions based on the combination of lipid microspheres with acoustic energy administered to a patient’s body.

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Marshall Stoller, MD

Robert Grubbs, PhD (deceased)

Thomas Kenny, PhD

Claire Mills, RDMS, RVT

Dan Laser, PhD

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Remembering Robert Grubbs, Co-Founder of Applaud Medical